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The Painted Veil by Somerset Maugham
Kitty Fane has married Walter so she can be married before her younger sister. But she doesn't love him. Walter is a bacteriologist who is vacationing from his work in Hong Kong. After their arrival, Kitty meets and falls in love with a diplomat. But Walter finds out about their affair and insists she accompany him to China where he is going to try to help with a cholera outbreak.
Kitty doesn't start out as a very sympathetic character. But as the book goes on you learn what motivates her. Very slowly she grows on you. "The Painted Veil" is a very easy book to read...flowing language and believable characters. I'd recommend it to everyone.