From the Corner of His Eye by Dean Koontz
Bartholomew Lampion is born on the day his father dies. By the age of three he loses his eyesight. He has also developed into a mathematical prodigy.
On the day of his birth, another child is born. Angel White is artistic. She is a result of a rape. Her mother dies on childbirth and she is raised by her Aunt Celestine.
Enoch Cain Jr. is as crazy as they come. He's a fan of a self-help guru who has committed suicide. In the beginning of the book he kills the wife he deeply loves by pushing her off a fire tower. The authorities award him a huge settlement. But Detective Tom Vanadium doesn't believe his story. And Cain has decided someone named Bartholemew is his mortal enemy.
Cain's search for this enemy causes him to commit several murders. And it brings together the two young prodigies.